|
| 胰癌的產生與許多因素有關；包括生活習慣(如吸煙)、作息、種族、遺傳、醫療健康狀況、飲食、外科手術史等。以下略加說明：
| 危險因素 |
| 1.生活習慣、作息
|
吸煙(與劑量有關) |
| 缺乏運動 |
| 2.種族
|
黑人男性 |
| 女性夏威夷土著 |
| 德系猶太人 (或許與 BRCA2 基因有關) |
| 3. 遺傳 |
遺傳性乳癌及卵巢癌 (BRCA2) |
| 家族性非典型性多痣性黑色素瘤 |
| P-J症候群 |
| 遺傳性胰腺炎 |
|
4. 醫療狀況及病史
|
肝硬化 |
| 糖尿病 |
| 慢性胰炎 |
| 5. 飲食 |
高脂肪/膽固醇 |
| 酒精 |
| 食物中的亞硝基化劑 |
| 6.外科手術 |
胃及膽囊手術 |
參考資料
- Silverman DT, Schiffman M, Everhart J, Goldstein A,
Lillemoe KD, Swanson GM, et al. Diabetes mellitus, other
medical conditions and familial history of cancer as risk
factors for pancreatic cancer. Br J Cancer 1999;80:1830-7.
- Mulder I, van Genugten MLL, Hoogenveen R, de Hollander
AEM, Bueno-de-Mesquita HB. The impact of smoking on future
pancreatic cancer: a computer simulation. Ann Oncol 1999;10:S74-S78.
- Ghadirian P, Liu G, Gallinger S, Schmocker B, Paradis
AJ, Lal G, et al. Risk of pancreatic cancer among individuals
with a family history of cancer of the pancreas. Int J
Cancer 2002;97:807-10.
- Klein AP, Petersen GM, Beaty TH, Bailey-Wilson JE,
Hruban RH. Statistical evidence for a novel major gene
involved in pancreatic cancer. Genetic Epidemiology 2002;23:133-49.
- Cancer risks in BRCA2 mutation carriers: the Breast
Cancer Linkage Consortium. J Natl Cancer Inst. 1999;91:1310-6.
- Murphy KM, Brune KA, Griffin CA, Hruban RH, Kern
SE. Candidate genes MAP2K4,
MADH4, and BRCA2 in familial pancreatic cancer. Cancer
Res 2002; 62:3789-93.
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